人羊膜由上皮細(xì)胞層、基底膜和無血管基質(zhì)組成。羊膜上皮細(xì)胞（AEC）在受精后第8天由外胚層形成。AEC可能是胚胎起源的結(jié)果，缺乏主要的組織相容性復(fù)合抗原，已被用于同種異體移植治療溶酶體疾病。研究表明，AEC具有乙酰膽堿和兒茶酚胺的合成和釋放以及DA受體和DA轉(zhuǎn)運(yùn)體mRNA的表達(dá)等多種功能。它們表達(dá)神經(jīng)元和膠質(zhì)細(xì)胞標(biāo)記，產(chǎn)生堿性成纖維細(xì)胞生長因子和肝細(xì)胞生長因子，并轉(zhuǎn)化生長因子β。人AEC被認(rèn)為是研究DA釋放和攝取過程、受體信號轉(zhuǎn)導(dǎo)和探索新開發(fā)的藥物的合適的人類細(xì)胞模型受體。血液病從阿克森研究實(shí)驗(yàn)室分離出人羊膜。血液在第一道通道被冷凍保存并冷凍運(yùn)送。每小瓶1毫升容量中含有>5×10^5個細(xì)胞。血液病的特征是免疫熒光法檢測細(xì)胞角蛋白-18、-19和波形蛋白抗體。細(xì)胞經(jīng)HIV-1，HBV，HCV，支原體，細(xì)菌，酵母和真菌檢測，陰性。在AcceGen研究實(shí)驗(yàn)室提供的條件下，HAEpiC可達(dá)15倍增

Human amniotic membrane is composed of an epithelial cell layer, a basement membrane and an avascular matrix. The amniotic epithelial cells (AEC) are formed from epiblasts on the 8th day after fertilization. A probable result of their embryonic origin, AEC lack major histocompatibility complex antigens and have been used for allotranplantation to treat patients with lysosomal diseases. Studies have shown that AEC have multiple functions such as synthesis and release of acetylcholine and catecholamine as well as expressing mRNA coding for DA receptors and DA transporters. They express neuronal and glial cell marks, produce basic fibroblast growth factors and hepatocyte growth factors and transform growth factor-beta. Human AEC has been suggested as an appropriate human cell model for studying DA release and uptake processes, receptor signal transduction and exploring newly developed drugs acting at these receptors.HAEpiC from AcceGen Research Laboratories are isolated from human amniotic membranes. HAEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HAEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAEpiC are guaranteed to further expand for 15 population doublings in the condition provided by AcceGen Research Laboratories.

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