星形膠質(zhì)細(xì)胞構(gòu)成哺乳動(dòng)物大腦的大部分細(xì)胞。它們是類(lèi)型最多變的，與神經(jīng)元的所有部分密切相關(guān)，因此在它們與神經(jīng)元的關(guān)系中最有趣的功能。它們?yōu)樯窠?jīng)元提供結(jié)構(gòu)、營(yíng)養(yǎng)和代謝支持，并調(diào)節(jié)突觸活動(dòng)。這些星形膠質(zhì)細(xì)胞功能在中風(fēng)和其他損傷中受損，可嚴(yán)重影響神經(jīng)元的存活。此外，星形膠質(zhì)細(xì)胞參與了許多神經(jīng)系統(tǒng)疾病的病理過(guò)程。腦損傷后的長(zhǎng)期恢復(fù)，通過(guò)神經(jīng)突生長(zhǎng)、突觸可塑性或神經(jīng)元再生，受到星形細(xì)胞表面分子表達(dá)和營(yíng)養(yǎng)因子釋放的影響。此外，星形膠質(zhì)細(xì)胞本身的死亡或存活也可能影響最終的臨床結(jié)果。越來(lái)越多的人認(rèn)識(shí)到星形膠質(zhì)細(xì)胞在神經(jīng)系統(tǒng)功能中的重要性，特別是在調(diào)節(jié)神經(jīng)活動(dòng)方面。我們對(duì)星形膠質(zhì)細(xì)胞的了解大多來(lái)自體外研究，而星形膠質(zhì)細(xì)胞培養(yǎng)繼續(xù)為探索這些細(xì)胞的不同特性提供了有用的工具。AcceGen研究實(shí)驗(yàn)室的HA-bs是從人腦干中分離出來(lái)的。在P1代凍存運(yùn)輸。每瓶包含>5×10^5細(xì)胞，體積為1ml。用GFAP抗體免疫熒光法對(duì)HA-bs進(jìn)行了表征。HA-bs對(duì)HIV-1、HBV、HCV、支原體、細(xì)菌、酵母和真菌均檢測(cè)陰性。在AcceGen研究實(shí)驗(yàn)室提供的條件下，HA-bs可達(dá)到15倍增，

Astrocytes make up the majority of the cells in the mammalian brain. They are the most variable in type, most intimately associated with all parts of neurons, and thus most functionally interesting in their relationships with neurons. They provide structural, trophic, and metabolic support to neurons and modulate synaptic activity. Impairment of these astrocyte functions during stroke and other insults can critically influence neuron survival. Furthermore, astrocytes have been implicated in the pathological processes of many neurological diseases. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is influenced by astrocyte surface molecule expression and trophic factor release. In addition, the death or survival of astrocytes themselves may affect the ultimate clinical outcome. Recognition of the importance of astrocytes in nervous system functioning is increasing, specifically regarding the modulation of neural activity. Much of what we have learned about astrocytes is from the in vitro studies and astrocyte cultures are continuing to provide a useful tool in exploring the diverse property of these cells.HA-bs from AcceGen Research Laboratories are isolated from human brain stem. HA-bs are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HA-bs are characterized by immunofluorescent method with antibody to GFAP. HA-bs are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HA-bs are guaranteed to further expand for 15 population doublings at the conditions provided by AcceGen Research Laboratories.

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