Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-?B luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-?B transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.

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