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當(dāng)前位置：首頁 > 產(chǎn)品中心(Products) > 定制細(xì)胞(Customized Cells) > 穩(wěn)轉(zhuǎn)細(xì)胞株(Transfected Stable Cell Lines) > 示蹤/報告細(xì)胞株(Report Transfection cell line) > Notch信號通路Notch1/CSL報告細(xì)胞系HEK293
產(chǎn)品描述/Products Description
The Notch CSL Reporter – HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by γ-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway.
