由一名84歲男性患者的頰粘膜（20mm-40mm）鱗狀細(xì)胞癌（SCC）建立。STNMPⅡ期，高分化，淋巴結(jié)陽(yáng)性腫瘤。突變型p53，密碼子306外顯子8，G至A；野生型K-，N-和Ha-ras。皮下注射和口底注射（原位）在裸鼠體內(nèi)不致瘤，但皮下形成表皮樣囊腫。

動(dòng)物種別：人類

組織來(lái)源 :口腔黏膜

形態(tài):上皮細(xì)胞樣，貼壁生長(zhǎng)

培養(yǎng)基配方：

89%DMEM:F12(MD0600）+2mM谷氨酰胺(SD0007）+10%FBS(SD0200）+0.5 ug/ml氫化可的松鈉+G/A(SD0038）

凍存條件：基礎(chǔ)培養(yǎng)基+5%DMSO+20%FBS(SD0200)

完全凍存液：免程序降溫細(xì)胞凍存液（低血清）(SD0001)

聲明：產(chǎn)品僅科研使用。

PubMed=1692339; DOI=10.1002/path.1711600313

Prime S.S., Nixon S.V., Crane I.J., Stone A., Matthews J.B., Maitland N.J., Remnant L., Powell S.K., Game S.M., Scully C.

The behaviour of human oral squamous cell carcinoma in cell culture.

J. Pathol. 160:259-269(1990)

PubMed=1744799; DOI=10.1002/path.1711650208

Mutlu S., Matthews J.B., Midda M., Scully C., Prime S.S.

MHC antigen expression in human oral squamous carcinoma cell lines.

J. Pathol. 165:129-136(1991)

PubMed=7633286; DOI=10.1016/0964-1955(94)00030-8

Yeudall W.A., Paterson I.C., Patel V., Prime S.S.

Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.

Eur. J. Cancer B Oral Oncol. 31:136-143(1995)