背景介紹/context：

Decidualization of the endometrium, mainly induced by progesterone, is a process of endometrial remodelling where the endometrial stromal cells differentiate into secretory decidual cells in preparation for pregnancy. Decidualized endometrial stromal cells are characterized by release of prolactin (PRL), RI-like growth factor binding protein-1 (IGFBP-1), tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1), and expression of basal lamina components such as laminin, collagen IV, and fibronectin. 

Immortalised Human Endometrial Stromal Cells (HESC) are unique in that 1) they display normal karyotype and 2) they respond to hormone stimulation and retain the morphological pattern and biochemical endpoints of decidualization after treatment of oestradiol and medroxyprogesterone, making this cell line a valuable tool in endometrium homeostasis and female reproductive studies.

子宮內(nèi)膜蛻膜化是子宮內(nèi)膜重構(gòu)的一個(gè)過(guò)程，主要由孕酮引起，子宮內(nèi)膜基質(zhì)細(xì)胞分化為分泌蛻膜細(xì)胞，為妊娠做準(zhǔn)備。蛻膜化的子宮內(nèi)膜基質(zhì)細(xì)胞的特征是泌乳素(PRL)、蛋白樣生長(zhǎng)因子結(jié)合蛋白-1 (IGFBP-1)、組織因子(TF)、纖溶酶原激活物抑制因子-1 (PAI-1)的釋放，以及層粘連蛋白、IV型膠原和纖連蛋白等基礎(chǔ)層結(jié)構(gòu)成分的表達(dá)。

人永生化子宮內(nèi)膜基質(zhì)細(xì)胞(HESC)是獨(dú)一無(wú)二的,1)他們顯示正常核型和2)應(yīng)對(duì)荷爾蒙刺激和保留的形態(tài)和生化模式端點(diǎn)decidualization甲羥孕酮和雌二醇治療后,做這個(gè)細(xì)胞株子宮內(nèi)膜內(nèi)穩(wěn)態(tài)和女性生殖研究中一個(gè)有價(jià)值的工具。

動(dòng)物種別/Organism  人

組織來(lái)源 Tissue and Cell Type 子宮內(nèi)膜

形態(tài)/Morphology 貼壁生長(zhǎng) 

注意事項(xiàng)：此產(chǎn)品僅供科研使用