背景介紹/context：

BEAS-2B cells were derived from normal bronchial epithelium obtained from autopsy of non-cancerous individuals. Cells were infected with a replication-defective SV40/adenovirus 12 hybrid and cloned. Squamous differentiation can be observed in response to serum. This ability can be used for screening chemical and biological agents inducing or affecting differentiation and/or carcinogenesis. The cell line has been applied for studies of pneumococcal infection mechanisms. BEAS-2B was described to express keratins and SV40 T antigen. Subculturing the cells before confluency is necessary as confluent cultures rapidly undergo squamous terminal differentiation.

BEAS-2B細(xì)胞來(lái)自于正常支氣管上皮，這些上皮來(lái)自于未癌變個(gè)體的尸檢。細(xì)胞被復(fù)制缺陷SV40/腺病毒12雜交體感染并克隆。在血清中可以觀察到鱗狀分化。這種能力可用于篩選誘導(dǎo)或影響分化和/或致癌的化學(xué)和生物制劑。該細(xì)胞系已應(yīng)用于肺炎球菌感染機(jī)制的研究。BEAS-2B表達(dá)角蛋白和sv40t抗原。融合前的細(xì)胞傳代是必要的，因?yàn)槿诤吓囵B(yǎng)迅速發(fā)生鱗狀終末分化。

動(dòng)物種別/Organism  人

組織來(lái)源 Tissue and Cell Type 支氣管

形態(tài)/Morphology 上皮細(xì)胞樣，貼壁生長(zhǎng) 

注意事項(xiàng)：此產(chǎn)品僅供科研使用