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人胰管上皮細(xì)胞系(H6c7)
貨號(hào)：IM035
價(jià)格： ￥詢(xún)價(jià)
產(chǎn)品描述/Products Description
背景介紹/context：
H6c7 is an immortalized epithelial cell line derived from normal human pancreatic duct epithelial (HPDE) cells. This cell line is an attractive model for human pancreatic duct cell carcinogenesis studies.
Highlights
Demonstrate near normal genotype and phenotype of HPDE cellsDisplay copy number of p16INK4A gene, wild type p53 and KRAS genesMorphologically similar to the primary HPDE cells, grow anchorage-dependently and do not form tumors in scid miceGrowth remains inhibited by transforming growth factor (TGF)-beta 1。
H6c7是一種來(lái)源于正常人胰腺導(dǎo)管上皮細(xì)胞(HPDE)的永生化上皮細(xì)胞系。該細(xì)胞系是一個(gè)有吸引力的模型，以人類(lèi)胰管細(xì)胞的癌變研究。
突出顯示，在scid細(xì)胞中，HPDE細(xì)胞接近正常基因型和表型，顯示p16INK4A基因拷貝數(shù)，野生型p53和KRAS基因形態(tài)與原代HPDE細(xì)胞相似，依賴(lài)于固定生長(zhǎng)，不形成腫瘤，生長(zhǎng)仍然受到轉(zhuǎn)化生長(zhǎng)因子(TGF)- 1的抑制。
動(dòng)物種別/Organism 人
組織來(lái)源 Tissue and Cell Type 胰腺導(dǎo)管上皮細(xì)胞
形態(tài)/Morphology 上皮細(xì)胞樣，貼壁生長(zhǎng)
注意事項(xiàng)：此產(chǎn)品僅供科研使用
