背景介紹/context：

Schwann cells are valuable tools for diabetic neuropathy pathogenesis involving glycation, reduced regenerative capability, oxidative stress, and other neurodegenerative diseases. The Immortalised Mouse Schwann Cells express glial cell markers (S100, GFAP, p75NTR); transcription factors involved in Schwann cell development and peripheral myelin formation (Krox20, Oct6, PAX3, and SOX10); and neurotrophic factors (NGF, BDNF, GDNF, and CNTF). In the presence of growth factors, such as PDGF-BB, aFGF, bFGF, or TGF-β1, these cells exhibit mitogenic reponses. The IMS32 cells may be used to study action mechanisms involved in peripheral nerve regeneration, and as an in vitro model to assess the pathogenesis of neurological diseases.

雪旺細(xì)胞是糖尿病神經(jīng)病變發(fā)病機(jī)制的寶貴工具，包括糖基化、再生能力降低、氧化應(yīng)激和其他神經(jīng)退行性疾病。永生化小鼠雪旺細(xì)胞表達(dá)膠質(zhì)細(xì)胞標(biāo)志物(S100, GFAP, p75NTR);參與雪旺細(xì)胞發(fā)育和周圍髓鞘形成的轉(zhuǎn)錄因子(Krox20、Oct6、PAX3和SOX10);以及神經(jīng)營養(yǎng)因子(NGF、BDNF、GDNF和CNTF)。在生長因子如PDGF-BB、aFGF、bFGF或TGF- 1存在的情況下，這些細(xì)胞表現(xiàn)出有絲分裂反應(yīng)。IMS32細(xì)胞可用于研究外周神經(jīng)再生的作用機(jī)制，并可作為評估神經(jīng)系統(tǒng)疾病發(fā)病機(jī)制的體外模型。

動物種別/Organism  小鼠

組織來源 Tissue and Cell Type 雪旺細(xì)胞

形態(tài)/Morphology 貼壁生長 

注意事項：此產(chǎn)品僅供科研使用