背景介紹/context：

Hepatic sinusoidal endothelial cells (HSECs) are an unique sub-population of liver that lines the hepatic sinusoids. Their role involves in clearing waste products from the blood, regulating pericyte contractility and innate immune functions. The Immortalised Mouse Hepatic Sinusoidal Endothelial Cells- SV40 is derived from C57BL/6 mouse HSECs that have maintained endothelial characteristics and HSEC-specific features such as vWF and caveolin-1. These cells also migrate in response to angiogenici growth factors, form vascular tube-like structures, endycytose acetylated low-density lipoprotein (AcLDL) and secrete proteins involved in matrix remodelling. In addition, these cells are easily transduced by retrovirus. The Immortalised Mouse Hepatic Sinusoidal Endothelial Cells- SV40 is therefore suitable for studying liver endothelial cell biology, including motility and angiogenesis.

肝竇內(nèi)皮細(xì)胞(HSECs)是排列在肝竇內(nèi)的一種獨特的肝臟亞群。它們的作用包括清除血液中的廢物，調(diào)節(jié)周細(xì)胞收縮能力和先天免疫功能。小鼠肝竇內(nèi)皮細(xì)胞- SV40來源于C57BL/6小鼠HSECs，這些HSECs維持了內(nèi)皮細(xì)胞特征和HSECs特異性特征，如vWF和caveolin-1。這些細(xì)胞還會響應(yīng)血管原性生長因子而遷移，形成血管管樣結(jié)構(gòu)，乙?；兔芏戎鞍?AcLDL)并分泌參與基質(zhì)重構(gòu)的蛋白。此外，這些細(xì)胞容易被逆轉(zhuǎn)錄病毒轉(zhuǎn)導(dǎo)。因此，小鼠肝竇內(nèi)皮細(xì)胞- SV40適于研究肝臟內(nèi)皮細(xì)胞生物學(xué)，包括運動性和血管生成。

動物種別/Organism  小鼠

組織來源 Tissue and Cell Type 肝竇內(nèi)皮細(xì)胞

形態(tài)/Morphology 內(nèi)皮細(xì)胞樣，貼壁生長 

注意事項：此產(chǎn)品僅供科研使用