背景介紹/context：

As messengers bridging the innate and adaptive immune system, the conventional tissue-resident DC (cDC) acts as sentinels in secondary lymphoid organs and other tissues for antigen capture and presentation. The Wild-type MutuDC1940 cell line is an Immortalised splenic CD8α+ subset (CD11chigh,B220-,DEC205+,CD24high,CD11b-) of conventional dendritic cells derived from the CD11c:SV40LgT transgenic mice. The MutuDC1940 cell line retains response to TLR ligands such as CpG (TLR9-L) and PolyIC (TLR3-L) and to a lesser extent LPS (TLR4-L) stimulation by up-regulation of co-stimulatory molecules CD40, CD80 and CD86. In addition to responding to PAMP stimulation and producing Th1 cytokines such as IL-12, these cells are also capable of presenting antigen in the context of both MHC-I and MHC-II, including direct antigen presentation and cross-presentation of cell-associated antigens.

作為連接先天免疫系統(tǒng)和適應(yīng)性免疫系統(tǒng)的信使，傳統(tǒng)的組織常駐DC (cDC)在次級(jí)淋巴器官和其他組織中充當(dāng)抗原捕獲和遞呈的哨兵。野生型MutuDC1940細(xì)胞系是來(lái)自CD11c:SV40LgT轉(zhuǎn)基因小鼠的傳統(tǒng)樹(shù)突狀細(xì)胞的永存脾臟cd8 & alpha +亞群(CD11chigh,B220-，DEC205+，CD24high,CD11b-)。MutuDC1940細(xì)胞系保留了對(duì)TLR配體如CpG (TLR9-L)和PolyIC (TLR3-L)以及LPS (TLR4-L)刺激的響應(yīng)，通過(guò)上調(diào)共刺激分子CD40、CD80和CD86。除了對(duì)PAMP刺激產(chǎn)生反應(yīng)和產(chǎn)生Th1細(xì)胞因子如IL-12，這些細(xì)胞還能夠在MHC-I和MHC-II環(huán)境下呈遞抗原，包括直接抗原呈遞和細(xì)胞相關(guān)抗原交叉呈遞。

動(dòng)物種別/Organism 小鼠

組織來(lái)源 Tissue and Cell Type 樹(shù)突狀細(xì)胞

形態(tài)/Morphology 神經(jīng)細(xì)胞樣，貼壁生長(zhǎng) 

注意事項(xiàng)：此產(chǎn)品僅供科研使用