背景介紹/context：

Mocha cells are a rat cochlear microglial cell line. They were developed from an immunomagnetically enriched population of CD11b+ cells from P3 rat cochlea and Immortalised with the 12S E1A gene of adenovirus in a replication-incompetent retroviral vector.Microglia are a unique lineage of mononuclear phagocytic cells that play an essential role in development, immunological defense and in- flammatory processes in the central nervous system. Microglia account for 10-15% of all cells found within the brain. As the resident macrophage cells, they act as the first and main form of active immune defence in the central nervous system (CNS).

Mocha細(xì)胞是一種大鼠耳蝸小膠質(zhì)細(xì)胞系。它們是由P3大鼠耳蝸中免疫磁性富集的CD11b+細(xì)胞培養(yǎng)而來，并在一種不具備復(fù)制能力的逆轉(zhuǎn)錄病毒載體中以腺病毒的12S E1A基因永生。小膠質(zhì)細(xì)胞是一種獨(dú)特的單核吞噬細(xì)胞譜系，在中樞神經(jīng)系統(tǒng)的發(fā)育、免疫防御和燃燒過程中發(fā)揮重要作用。小膠質(zhì)細(xì)胞占腦內(nèi)所有細(xì)胞的10-15%。巨噬細(xì)胞作為體內(nèi)的巨噬細(xì)胞，在中樞神經(jīng)系統(tǒng)(CNS)中是第一種也是主要的主動(dòng)免疫防御形式。

動(dòng)物種別/Organism  大鼠

組織來源 Tissue and Cell Type 耳蝸小膠質(zhì)細(xì)胞

形態(tài)/Morphology 貼壁生長(zhǎng) 

注意事項(xiàng)：此產(chǎn)品僅供科研使用